Ambroxol hydrochloride terbutaline sulphate guaiphenesin & menthol syrup

RP-HPLC-UV method development and validation for simultaneous determination of terbutaline sulphate, ambroxol HCl and guaifenesin in pure and dosage forms - ScienceDirect JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article Original article RP-HPLC-UV method development and validation for simultaneous determination of terbutaline sulphate, ambroxol HCl and guaifenesin in pure and dosage forms Développement et validation de la méthode RP-HPLC-UV pour la détermination simultanée du sulfate de terbutaline, du chlorhydrate d’ambroxol et de la guaifénésine dans des formes pures et dosées Method The combination of these drugs was analyzed by using Shimadzu LC 2010 CHT high performance liquid chromatography (HPLC). Successful separation was achieved by isocratic elution on a reverse-phase C 18 column (sun fire) (250mm, 4.6mm, 5μ), using a mobile phase consisting of buffer: acetonitrile in the ratio 80: 20 (buffer − 0.1% v/v triethyleamine pH-3.0) followed by 1.0mL/min flow rate. The wavelength of detection was at 220nm. Result The chromatographic retention times were consistent at 3.0, 10.5 and 13.8minutes for TSL, AML and GFN respectively. For these three compounds, the lower limit of detection was 1.0, 1.25, and 1.5μg/mL and lower limit of quantification was 3.3, 4.1 and 5.0μg/mL respectively. The linearity concentrations established for TSL, AML and GFN were 1.0–7.0, 1.5–7.5 and 4.0–14.0μg/m...

Ambroxol + Guaifenesin + Menthol + Terbutaline is a combination of four medicines: Ambroxol , Guaifenesin , Menthol and Terbutaline. Ambroxol is a mucolytic which thins and loosens mucus (phlegm), making it easier to cough out. Guaifenesin is an expectorant which works by decreasing the stickiness of airway secretions and helps in their removal from the airways. Menthol is an organic compound which produces a sensation of coolness and relieves minor throat irritation. Terbutaline is a bronchodilator which relaxs the muscles in the airways and widens the airways.Together, they make breathing easier. • Ambroxol + Guaifenesin + Menthol + Terbutaline relieves cough associated with bronchitis, bronchial asthma, emphysema and other broncho-pulmonary disorders. • It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you. • If you are diabetic, monitor your blood glucose regularly while taking this medicine. • Inform your doctor if you have a history of thyroid or heart disease. • Stop taking Ambroxol + Guaifenesin + Menthol + Terbutaline and inform your doctor if your cough persists for more than 1 week, tends to recur, or is accompanied by a fever, rash or persistent headache. Q. Will a higher than the recommended dose of Ambroxol+Guaifenesin+Menthol+Terbutaline be more effective? No, taking higher than the recommended dose may not be more effective, rather it may increase the chances of having increased side ...

Ambroxol Hydrochloride Dosage form: tablets, syrup Medically reviewed by • • • • • Composition: each tablet contains ambroxol hydrochloride 30 mg; each 5 ml of the syrup contains ambroxol hydrochloride 15 mg. What is Ambroxol? Ambroxol works to thin down and break up phlegm (sputum) and is used to clear congestion in the treatment of respiratory diseases which have thick phlegm or too much phlegm. Ambroxol is also used as a pain reliever for sore throats as it has a local numbing effect. Ambroxol starts working about 30 minutes after it has been taken. The breakdown of acid mucopolysaccharide fibers makes the sputum thinner and less viscous and therefore more easily removed by coughing. Although sputum volume eventually decreases, its viscosity remains low for as long as treatment is maintained. Ambroxol Indications All forms of tracheobronchitis, emphysema with bronchitis pneumoconiosis, chronic inflammatory pulmonary conditions, bronchiectasis, bronchitis with bronchospasm asthma. During acute exacerbations of bronchitis it should be given with the appropriate antibiotic. Ambroxol Contraindications There are no absolute contraindications but in patients with gastric ulceration relative caution should be observed. Ambroxol Side effects Occasional gastrointestinal side effects may occur but these are normally mild. Precautions It is advisable to avoid use during the first trimester of pregnancy. Ambroxol Dosage Adults: daily dose of 30 mg (one Ambroxol tablet ) to 120 mg (...

Ambroxol is primarily prescribed to treat sore throat. It is prescribed along with other medications to treat cough and related respiratory issues. This drug can be found in many of the cough syrups and various other medications treating the same. Ambroxol is a drug, used to cure respiratory diseases. This drug clears the respiratory tract and breaks up the phlegm. It aids in the release of surfactant which in turn prevents the mucus from sticking to the bronchial wall. This medication is an active ingredient found in cough syrups which facilitates easy breathing in case of clogging up of the nasal cavity. Each tablet of this drug contains 30 mg hydrochloride whereas every 15 ml contains 15mg of ambroxol hydrochloride. Its action begins quickly just 30 mins after intake. This is clinically proven to make the sputum thinner and less vicious and helps to cure cough. It is also used to treat different forms of inflammatory pulmonary conditions, bronchitis, bronchospasm asthma and pneumoconiosis. • Is It safe with alcohol? Interaction of this drug with alcohol is specifically not known. Therefore it is advisable to consult the medical practitioner in such situations. • Are there any pregnancy warnings? Women who are pregnant must consult doctor before using this medication. • Are there any breast-feeding warnings? It has negative effects in relation to breastfeeding as it is excreted into the breast milk and may harm the infant. In case it is essential, alternative forms of me...

Ambroxol + Guaifenesin + Terbutaline is a combination of three medicines: Ambroxol , Guaifenesin and Terbutaline, which relieves cough with mucus. Ambroxol is a mucolytic which thins and loosens mucus (phlegm), making it easier to cough out. Guaifenesin is an expectorant which decreases the stickiness of mucus (phlegm) and helps in its removal from the airways. Terbutaline is a bronchodilator. It works by relaxing the muscles in the airways and widens the airways. Together, they make breathing easier. • Ambroxol + Guaifenesin + Terbutaline relieves cough accompanied with mucus that is associated with broncho-pulmonary disorders such as bronchitis, bronchial asthma and emphysema. • It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you. • If you are diabetic, monitor your blood glucose regularly while taking this medicine. • Inform your doctor if you have a history of thyroid or heart disease. • Stop taking Ambroxol + Guaifenesin + Terbutaline and inform your doctor if your cough persists for more than 1 week, tends to recur, or is accompanied by a fever, rash or persistent headache. Q. Will a higher than the recommended dose of Ambroxol+Guaifenesin+Terbutaline be more effective? No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having serious side effects. If the recommended dosage does not relieve your symptoms or there is an increased seve...

AMBROXOL+GUAIPHENESIN+TERBUTALINE belongs to the class of medicines called expectorantsprimarily used to treat cough associated with mucus. Coughing (dry or productive) is a body's way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection. There are two types of coughs, namely: Dry cough and chesty cough. A dry cough is tickly and doesn't produce any vicious or thick mucus, while a chesty cough (wet cough) produces mucous or sputum. AMBROXOL+GUAIPHENESIN+TERBUTALINE contains Ambroxol, Guaiphenesin and Terbutaline. Ambroxol works by thinning and loosening phlegm (mucus) in the lungs, windpipe and nose. Guaiphenesin increases the volume of fluid in the airways, reduces the stickiness of mucus, and removes it from the airways. Terbutaline relaxes muscles and widens the airways. Thereby, it makes breathing easier. Together, AMBROXOL+GUAIPHENESIN+TERBUTALINE helps provide relief from cough. Your doctor will recommend the dose and duration based on your medical condition. In some cases, youmay experience common side effects such as nausea, vomiting, drowsiness, headache, dizziness, nervousness, and stomach upset. Most of these side effectsdo not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Consult your doctor if you are pregnant or breastfeeding. AMBROXOL+GUAIPHENESIN+TERBUTALINE should be used with caution in children if prescribed by a doctor. If you...

Ambroxol + Guaifenesin + Terbutaline is a combination of three medicines: Ambroxol , Guaifenesin and Terbutaline, which relieves cough with mucus. Ambroxol is a mucolytic which thins and loosens mucus (phlegm), making it easier to cough out. Guaifenesin is an expectorant which decreases the stickiness of mucus (phlegm) and helps in its removal from the airways. Terbutaline is a bronchodilator. It works by relaxing the muscles in the airways and widens the airways. Together, they make breathing easier. • Ambroxol + Guaifenesin + Terbutaline relieves cough accompanied with mucus that is associated with broncho-pulmonary disorders such as bronchitis, bronchial asthma and emphysema. • It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you. • If you are diabetic, monitor your blood glucose regularly while taking this medicine. • Inform your doctor if you have a history of thyroid or heart disease. • Stop taking Ambroxol + Guaifenesin + Terbutaline and inform your doctor if your cough persists for more than 1 week, tends to recur, or is accompanied by a fever, rash or persistent headache. Q. Will a higher than the recommended dose of Ambroxol+Guaifenesin+Terbutaline be more effective? No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having serious side effects. If the recommended dosage does not relieve your symptoms or there is an increased seve...

RP-HPLC-UV method development and validation for simultaneous determination of terbutaline sulphate, ambroxol HCl and guaifenesin in pure and dosage forms - ScienceDirect JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article Original article RP-HPLC-UV method development and validation for simultaneous determination of terbutaline sulphate, ambroxol HCl and guaifenesin in pure and dosage forms Développement et validation de la méthode RP-HPLC-UV pour la détermination simultanée du sulfate de terbutaline, du chlorhydrate d’ambroxol et de la guaifénésine dans des formes pures et dosées Method The combination of these drugs was analyzed by using Shimadzu LC 2010 CHT high performance liquid chromatography (HPLC). Successful separation was achieved by isocratic elution on a reverse-phase C 18 column (sun fire) (250mm, 4.6mm, 5μ), using a mobile phase consisting of buffer: acetonitrile in the ratio 80: 20 (buffer − 0.1% v/v triethyleamine pH-3.0) followed by 1.0mL/min flow rate. The wavelength of detection was at 220nm. Result The chromatographic retention times were consistent at 3.0, 10.5 and 13.8minutes for TSL, AML and GFN respectively. For these three compounds, the lower limit of detection was 1.0, 1.25, and 1.5μg/mL and lower limit of quantification was 3.3, 4.1 and 5.0μg/mL respectively. The linearity concentrations established for TSL, AML and GFN were 1.0–7.0, 1.5–7.5 and 4.0–14.0μg/m...

Ambroxol Hydrochloride Dosage form: tablets, syrup Medically reviewed by • • • • • Composition: each tablet contains ambroxol hydrochloride 30 mg; each 5 ml of the syrup contains ambroxol hydrochloride 15 mg. What is Ambroxol? Ambroxol works to thin down and break up phlegm (sputum) and is used to clear congestion in the treatment of respiratory diseases which have thick phlegm or too much phlegm. Ambroxol is also used as a pain reliever for sore throats as it has a local numbing effect. Ambroxol starts working about 30 minutes after it has been taken. The breakdown of acid mucopolysaccharide fibers makes the sputum thinner and less viscous and therefore more easily removed by coughing. Although sputum volume eventually decreases, its viscosity remains low for as long as treatment is maintained. Ambroxol Indications All forms of tracheobronchitis, emphysema with bronchitis pneumoconiosis, chronic inflammatory pulmonary conditions, bronchiectasis, bronchitis with bronchospasm asthma. During acute exacerbations of bronchitis it should be given with the appropriate antibiotic. Ambroxol Contraindications There are no absolute contraindications but in patients with gastric ulceration relative caution should be observed. Ambroxol Side effects Occasional gastrointestinal side effects may occur but these are normally mild. Precautions It is advisable to avoid use during the first trimester of pregnancy. Ambroxol Dosage Adults: daily dose of 30 mg (one Ambroxol tablet ) to 120 mg (...

Ambroxol is primarily prescribed to treat sore throat. It is prescribed along with other medications to treat cough and related respiratory issues. This drug can be found in many of the cough syrups and various other medications treating the same. Ambroxol is a drug, used to cure respiratory diseases. This drug clears the respiratory tract and breaks up the phlegm. It aids in the release of surfactant which in turn prevents the mucus from sticking to the bronchial wall. This medication is an active ingredient found in cough syrups which facilitates easy breathing in case of clogging up of the nasal cavity. Each tablet of this drug contains 30 mg hydrochloride whereas every 15 ml contains 15mg of ambroxol hydrochloride. Its action begins quickly just 30 mins after intake. This is clinically proven to make the sputum thinner and less vicious and helps to cure cough. It is also used to treat different forms of inflammatory pulmonary conditions, bronchitis, bronchospasm asthma and pneumoconiosis. • Is It safe with alcohol? Interaction of this drug with alcohol is specifically not known. Therefore it is advisable to consult the medical practitioner in such situations. • Are there any pregnancy warnings? Women who are pregnant must consult doctor before using this medication. • Are there any breast-feeding warnings? It has negative effects in relation to breastfeeding as it is excreted into the breast milk and may harm the infant. In case it is essential, alternative forms of me...