Pitocin

Pitocin Side Effects Generic name: oxytocin Note: This document contains side effect information about oxytocin. Some dosage forms listed on this page may not apply to the brand name Pitocin. Applies to parenteral injection. Side effects include: Adverse effects usually are dose related. Uterine hyperstimulation and subsequent fetal heart rate deceleration most common. (See Uterine Hyperactivity under General Precautions.) Maternal Neonatal For Healthcare Professionals Applies to oxytocin: compounding powder, injectable solution, intravenous solution. General The more commonly reported adverse effects have included [ Cardiovascular Common (1% to 10%): Tachycardia, bradycardia Frequency not reported: Premature ventricular contractions, hypertensive episodes, cardiac Postmarketing reports: Myocardial ischemia, QTc prolongation, [ Bradycardia and premature ventricular contractions and other arrhythmias have been reported in the neonate due to induced uterine motility. [ Nervous system Permanent CNS or brain damage, and [ Common (1% to 10%): Headache Frequency not reported: [ Metabolic Frequency not reported: Severe water intoxication with convulsions, coma, fatal water intoxication Postmarketing reports: Maternal [ Hypersensitivity Frequency not reported: Postmarketing reports: Anaphylactic reaction and shock [ Genitourinary Frequency not reported: Uterine Rupture, pelvic hematoma, postpartum hemorrhage Postmarketing reports: Uterine hypertonicity, tetanic contractions, ruptu...

One trial with 809 participants reported a composite outcome of death or severe morbidity, defined as hysterectomy, transfer to higher care, organ dysfunction, coagulopathy, or shock. In this trial, there were two deaths (one in each treatment arm) and six hysterectomies (four in the misoprostol group, two in the oxytocin group), but the results were not clinically significant. , – Fever and vomiting were the most reported adverse effects across trials and occurred significantly more often in the misoprostol treatment arms. Out of 1,821 patients who received misoprostol, 650 developed a fever, compared with 206 out of 1,840 patients not taking misoprostol (absolute risk increase = 24.5%; 95% CI, 20.78 to 28.1). Vomiting was more common in the misoprostol arms but to a less significant extent (number needed to harm = 36; 95% CI, 21.9 to 81). – Caveats: The individual study quality in this Cochrane review was heterogeneous, with most available evidence rated as low certainty. Variable postpartum hemorrhage definitions, estimated blood volume loss in some trials, and different quantifiable inclusion thresholds (e.g., 700 mL vs. 500 mL) reduced the evidence certainty. , Variability in prophylactic and treatment doses of oxytocin and in delivery timing also limits external validity. Misoprostol dosing methods varied, including sublingual, rectal, oral, and combination doses from 400 mcg to 1,000 mcg. Although several patient-oriented outcomes were reported in this review, the i...

• You are more than 42 weeks pregnant and haven’t gone into labor. • Your • Your baby is experiencing • You have • You have premature rupture of membranes (PROM), meaning that your amniotic sac ruptured on its own but you aren’t having contractions. • You have • You have high blood pressure. • There are problems with your heart, kidneys, or other major organs. • There are In certain cases, it may not be safe to induce labor with Pitocin. Your healthcare provider may recommend that you have a C-section instead if certain conditions are present, such as: • • • Infection, such as genital herpes • Umbilical cord prolapse (when the umbilical cord drops into the birth canal before the baby) • Cervical cancer • A history of uterine surgery or prior C-sections Complications While rare, some serious medical complications are possible when using Pitocin to induce labor. Severe complications from Pitocin may include: • MedlinePlus. • Johns Hopkins Medicine. • MedlinePlus. • American College of Obstetricians and Gynecologists. • Nemours KidsHealth. • Daly D, Minnie KCS, Blignaut A, et al. PLoS One. 2020;15(7):e0227941. doi:10.1371/journal.pone.0227941 • Johns Hopkins Medicine. • Hidalgo-Lopezosa P, Hidalgo-Maestre M, Rodríguez-Borrego MA. Rev Lat Am Enfermagem. 2016;24:e2744. doi:10.1590/1518-8345.0765.2744 • The American College of Obstetricians and Gynecologists. • Cheong JL, Doyle LW, Burnett AC, et al. JAMA Pediatr. 2017;171(4):e164805. doi:10.1001/jamapediatrics.2016.4805 • Brahm...

Add a drug to check interactions Add • • View (1) • View (2) Most frequently checked interactions View interaction reports for Pitocin (oxytocin) and the medicines listed below. • Major • Moderate • Minor • Unknown • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Pitocin alcohol/food interactions There is Pitocin disease interactions There are • • Drug Interaction Classification These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Unknown No interaction information available. Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Inside: Five differences between We often call it The Love Hormone, but did you know that Yep, it’s true. (1) Although we later discovered that it does a lot of beautiful things –strengthen emotional bonds, facilitate trust and reduce the effects of stress, for example – oxytocin was named when the only thing we really understood about it was that it’s essential for birth. Now, chemically speaking oxytocin and its synthetic equivalent – Pitocin – are identical.You’d think that their effects would are identical, too, but actually that’s not the case. There is some overlap, but there are also huge differences. The Difference Between Oxytocin and Pitocin Let’s start with what they have in common:Both oxytocin and Pitocin stimulate contractions during labor and get mama’s milk flowing after the baby is born. Oxytocin also helps the uterus contract after birth and controls bleeding. Pitocin is sometimes used to control bleeding as well, however it’s important to note that when Pitocin is given before the third stage of labor (for example, maybe it was given earlier to induce or augment labor), it actually increases the risk of postpartum hemorrhage. We’ll discuss why below, along with five differences between oxytocin and Pitocin thatmay affect how we experience labor, birth, and bonding: 1. Oxytocin Triggers The Endorphin Effect Birth is intense. Understatement of the year, right? Fortunately, our bodies help us through it by producing beta-endorphins, which are18 to 33 times ...

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. The dosage of oxytocin is determined by the uterine response and must therefore be individualized and initiated at a very low level. The following dosage information is based upon various regimens and indications in general use. A. Induction or Stimulation of Labor Intravenous infusion (drip method) is the only acceptable method of parenteral administration of Pitocin for the induction or stimulation of labor. Accurate control of the rate of infusion is essential and is best accomplished by an infusion pump. It is convenient to piggyback the Pitocin infusion on a physiologic electrolyte solution, permitting the Pitocin infusion to be stopped abruptly without interrupting the electrolyte infusion. This is done in the following way. • Preparation • The standard solution for infusion of Pitocin is prepared by adding the contents of one 1-mL vial containing 10 units of oxytocin to 1000 mL of 0.9% aqueous sodium chloride or Ringer's lactate. The combined solution containing 10 milliunits (mU) of oxytocin/mL is rotated in the infusion bottle for thorough mixing. • Establish the infusion with a separate bottle of physiologic electrolyte solution not containing Pitocin. • Attach (piggyback) the Pitocin-containing bottle with the infusion pump to the infusion line as close to the infusion site as possible. • Administration Th...