Superantigen

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TUCSON, Ariz., June 06, 2022 (GLOBE NEWSWIRE) -- Autopsies of two young boys who died of heart problems shortly after COVID-19 vaccination showed a pattern consistent with a toxic stress injury to the heart muscle, writes Journal of American Physicians and Surgeons. A detailed look at the spike protein of the SARS-CoV-2 virus and the protein coded for by the mRNA vaccine reveals the presence of a “superantigen” motif. This unique sequence is not present in other known SARS-related β-coronaviruses. But it is similar both in function and three-dimensional structure to staphylococcal enterotoxin B. SEB is a potent toxin produced by Staphylococcus aureus bacteria. Notably, SEB was manufactured on a large scale as a biological weapon during the 1960s. It is reasonable to assume that the hyperinflammatory syndrome of COVID-19 can originate from the superantigen sequence, writes Dr. Hatfill, and that this syndrome might also occur in some vaccine recipients. Since there is no apparent natural evolutionary lineage for the superantigen sequence, a laboratory origin must be considered, he states. If the SEB-like motif present in the virus proves to be an intentional genetic insert, this technology represents a dramatic advancement in offensive biological warfare. The discovery of the sequence in the spike protein of SARS-CoV-2 was published in the Proceedings of the National Academy of Sciences in September 2020, Dr. Hatfill reports, but its significance is only now receiving attent...

Crystallographic structure of TSST-1 Identifiers Organism Symbol tst Search for Structures Domains Toxic shock syndrome toxin-1 ( TSST-1) is a Characteristics [ ] Toxic shock syndrome toxin-1 (TSST-1), a prototype Structure [ ] In the nucleotide sequence of TSST-1, there is a 708 base-pair open-reading frame and a Production [ ] TSST-1 is a protein encoded by the tst gene, which is part of the S. aureus, which indicates its importance in establishing infection. TSST-1 differs from other PTSAgs in that its genetic sequence does not have a homolog with other superantigen sequences. agr ( S. aureus genes, including TSST-1. ssrB and srrAB affect the Mutations [ ] Based on studies of various mutations of the protein it appears that the superantigenic and lethal portions of the protein are separate. Isolation [ ] Samples of TSST-1 can be purified from bacterial cultures to use in in vitro testing environments, however this is not ideal due to the large number of factors that contribute to pathenogenesis in an in vivo environment. in vitro provides an environment which is rich in nutrients, in contrast to the reality of an in vivo environment, in which nutrients tend to be more scarce. in vitro or for animal models using a mini-osmotic pump. Mechanism [ ] A superantigen such as TSST-1 stimulates human T cells that express VB 2, which may represent 5-30% of all host T cells. PTSAgs induce the VB-specific expansion of both CD4 and CD8- subsets of T-lymphocytes. TSST-1 forms homodim...