Welovead mppd

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The MPPD model calculates the deposition and clearance of monodisperse and polydisperse aerosols in the respiratory tracts of laboratory animals and human adults and children (deposition only) for particles ranging in size from ultrafine (1 nm) to coarse (100 µm). Respiratory tract dosimetry models have been developed for several laboratory animal species including rat, mouse, rhesus monkey, pig, and rabbit. The models are based on single-path and multiple-path methods for tracking air flow and calculating aerosol deposition in the lung. The single-path method calculates deposition in a typical path per airway generation, while the multiple-path method calculates particle deposition in all airways of the lung and provides lobar-specific and airway-specific information. Within each airway, deposition is calculated using theoretically-derived efficiencies for deposition by diffusion, sedimentation, and impaction within the airway or airway bifurcation. Filtration of aerosols by the nose and mouth is determined using empirically-derived efficiency equations. The MPPD model includes calculations of particle clearance in the lung following deposition for humans, rats, and mice. Eight tutorials are provided so that the user can learn to interact with the software. If you have any questions, please contact References Anjilvel, S. and Asgharian, B. (1995). A multiple-path model of particle deposition in the rat lung. Fundam. Appl. Toxicol. 28, 41-50. National Institute for Public ...