Dapagliflozin and metformin

What Is Xigduo XR? Xigduo XR (dapagliflozin and metformin HCl) is a combination of two oral antihyperglycemic medications used as an adjunct to diet and exercise to improve glycemic control in adults with What Are Side Effects of Xigduo XR? Xigduo XRmay cause serious side effects including: • hives, • difficulty breathing, • swelling of your face, lips, tongue, or throat, • bladder pain, • bloody urine, • cloudy urine, • change in color, amount, or odor of vaginal discharge, • burning or painful urination, • frequent urge to urinate, • lower back or side pain, • decreased appetite, • diarrhea, • fast or shallow breathing, • general ill feeling, • muscle pain or cramping, • nausea, • sleepiness, • stomach pain, • unusual tiredness or weakness, • anxiety, • blurred vision, • chills, • clay-colored stools, • cold sweats, • pale skin, • depression, • lightheadedness, • fast heartbeat, • fever, • headache, • itches, • dizziness, • hoarseness, • increased appetite, • irritation, • joint pain, stiffness, or swelling, • loss of appetite, • loss of consciousness, • nightmares, • pain, tenderness, redness, or swelling of the area between the anus and genitals, • redness of the skin, • seizures, • tremors, • shakiness, • slurred speech, • sweating, • tightness in the chest, • difficulty swallowing, • unpleasant breath odor, • vomiting blood, and • yellowing of the skin or eyes (jaundice) Get medical help right away, if you have any of the symptoms listed above. Common side effects of...

Description and Brand Names Drug information provided by: Descriptions Dapagliflozin, saxagliptin, and metformin combination is used with proper diet and exercise to lower high blood sugar levels caused by type 2 diabetes. Dapagliflozin works in the kidneys to prevent absorption of glucose (blood sugar). This helps lower the blood sugar level. Saxagliptin helps to control blood sugar levels by making the pancreas gland release more insulin. It also signals the liver to stop producing sugar when there is too much sugar in the blood. Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. This medicine does not help patients who have insulin-dependent or type 1 diabetes. Type 1 diabetic patients must use insulin injections. This medicine is available only with your doctor's prescription. • Portions of this document last updated: June 01, 2023 Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. • •

Dosage Forms & Strengths dapagliflozin/saxagliptin/metformin HCl extended-release tablet • 2.5mg/2.5mg/1000mg • 5mg/2.5mg/1000mg • 5mg/5mg/1000mg • 10mg/5mg/1000mg Type 2 Diabetes Mellitus Sodium-glucose cotransporter 2 (SGLT2) inhibitor, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and a biguanide combination product indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (DM) Individualize starting total daily dose based on the patient’s current regimen, effectiveness, and tolerability For patients not currently taking dapagliflozin, recommended starting dose is dapagliflozin 5 mg/saxagliptin 5 mg/metformin HCl extended-release 1000 mg or 2000 mg PO qDay Maximum recommended daily dose is dapagliflozin 10 mg/saxagliptin 5 mg/metformin HCl extended-release 2000 mg Dosage Modifications Renal impairment • Mild (eGFR ≥45 mL/min/1.73 m²): No dosage adjustment necessary • Moderate-to-severe (eGFR <45 mL/min/1.73 m²): Contraindicated • End-stage renal disease (ESRD) or patients on dialysis: Contraindicated Hepatic impairment • Not recommended; use of metformin in patients with hepatic impairment has been associated with some cases of lactic acidosis Dosing Considerations Discontinuation for iodinated contrast imaging procedures • Discontinue at time of, or prior to, an iodinated contrast imaging procedure in patients with a history of liver disease, alcoholism, or heart failure, or in patients who will be administered intra...

Boxed Warning Lactic acidosis Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Metformin-associated lactic acidosis was characterized by elevated blood lactate levels (>5 mmol/L), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ratio; and metformin plasma levels generally >5 mcg/mL. Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors such as topiramate), age ≥65 years, having a radiological study with contrast, surgery and other procedures, hypoxic states (eg, acute congestive heart failure), excessive alcohol intake, and hepatic impairment. Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided in the full prescribing information. If metformin-associated lactic acidosis is suspected, immediately discontinue and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended. Pharmacology Mechanism of Action See individual agents. Use: Labeled Indications Diabetes mellitus, type 2: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 ...

• • Dapagliflozin-Metformin Tablet, Immediate Release And Extended Release, Biphasic 24Hr (Tablet,Immed & Ext Release,Biphasic 24Hr) Dapagliflozin-Metformin Tablet, Immediate Release And Extended Release, Biphasic 24Hr (Tablet,Immed & Ext Release,Biphasic 24Hr) - Uses, Side Effects, and More Common Brand(S): Xigduo XR Generic Name(S): dapagliflozin-metformin View Free Coupon Read the Take this medication by The dosage is based on your medical condition, response to treatment, and other Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Tell your doctor if your condition does not improve or if it worsens (your See also Warning section. An empty tablet shell may appear in your stool. This effect is harmless because your body has already absorbed the Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: signs of a This medication may cause a new This medication does not usually cause Symptoms of high blood sugar ( This medication may cause you to become dehydrated. This can lead to serious kidney damage. Drink plenty of fluids to prevent A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or ...

We treat every type of cancer, including the most important one: yours. With cancer, where you get treated first matters. From diagnosis to treatment, our experts provide the care and support you need, when you need it. • • Adults • • • • • Children & Teens • • • • • Support, Services & Programs • • • • • • Cancer News & Discoveries • • • About Us • Rarely, metformin may cause too much lactic acid in the blood (lactic acidosis). The risk is higher in people who have kidney problems, liver problems, heart failure, use alcohol, or take other drugs like topiramate. The risk is also higher in people who are 65 or older and in people who are having surgery, an exam or test with contrast, or other procedures. If lactic acidosis happens, it can lead to other health problems and can be deadly. Kidney tests may be done while taking this drug. • Do not take this drug if you have a very bad infection, low oxygen, or a lot of fluid loss (dehydration). • Call your doctor right away if you have signs of too much lactic acid in the blood (lactic acidosis) like confusion; fast breathing; fast or slow heartbeat; a heartbeat that does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; feeling very tired or weak; very bad dizziness; feeling cold; or muscle pain or cramps. • It is used to lower blood sugar in patients with high blood sugar (diabetes). • It is used in certain people to lower the risk of death and having to go to the...

Dosage Forms & Strengths dapagliflozin/saxagliptin/metformin HCl extended-release tablet • 2.5mg/2.5mg/1000mg • 5mg/2.5mg/1000mg • 5mg/5mg/1000mg • 10mg/5mg/1000mg Type 2 Diabetes Mellitus Sodium-glucose cotransporter 2 (SGLT2) inhibitor, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and a biguanide combination product indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (DM) Individualize starting total daily dose based on the patient’s current regimen, effectiveness, and tolerability For patients not currently taking dapagliflozin, recommended starting dose is dapagliflozin 5 mg/saxagliptin 5 mg/metformin HCl extended-release 1000 mg or 2000 mg PO qDay Maximum recommended daily dose is dapagliflozin 10 mg/saxagliptin 5 mg/metformin HCl extended-release 2000 mg Dosage Modifications Renal impairment • Mild (eGFR ≥45 mL/min/1.73 m²): No dosage adjustment necessary • Moderate-to-severe (eGFR <45 mL/min/1.73 m²): Contraindicated • End-stage renal disease (ESRD) or patients on dialysis: Contraindicated Hepatic impairment • Not recommended; use of metformin in patients with hepatic impairment has been associated with some cases of lactic acidosis Dosing Considerations Discontinuation for iodinated contrast imaging procedures • Discontinue at time of, or prior to, an iodinated contrast imaging procedure in patients with a history of liver disease, alcoholism, or heart failure, or in patients who will be administered intra...

What Is Xigduo XR? Xigduo XR (dapagliflozin and metformin HCl) is a combination of two oral antihyperglycemic medications used as an adjunct to diet and exercise to improve glycemic control in adults with What Are Side Effects of Xigduo XR? Xigduo XRmay cause serious side effects including: • hives, • difficulty breathing, • swelling of your face, lips, tongue, or throat, • bladder pain, • bloody urine, • cloudy urine, • change in color, amount, or odor of vaginal discharge, • burning or painful urination, • frequent urge to urinate, • lower back or side pain, • decreased appetite, • diarrhea, • fast or shallow breathing, • general ill feeling, • muscle pain or cramping, • nausea, • sleepiness, • stomach pain, • unusual tiredness or weakness, • anxiety, • blurred vision, • chills, • clay-colored stools, • cold sweats, • pale skin, • depression, • lightheadedness, • fast heartbeat, • fever, • headache, • itches, • dizziness, • hoarseness, • increased appetite, • irritation, • joint pain, stiffness, or swelling, • loss of appetite, • loss of consciousness, • nightmares, • pain, tenderness, redness, or swelling of the area between the anus and genitals, • redness of the skin, • seizures, • tremors, • shakiness, • slurred speech, • sweating, • tightness in the chest, • difficulty swallowing, • unpleasant breath odor, • vomiting blood, and • yellowing of the skin or eyes (jaundice) Get medical help right away, if you have any of the symptoms listed above. Common side effects of...

We treat every type of cancer, including the most important one: yours. With cancer, where you get treated first matters. From diagnosis to treatment, our experts provide the care and support you need, when you need it. • • Adults • • • • • Children & Teens • • • • • Support, Services & Programs • • • • • • Cancer News & Discoveries • • • About Us • Rarely, metformin may cause too much lactic acid in the blood (lactic acidosis). The risk is higher in people who have kidney problems, liver problems, heart failure, use alcohol, or take other drugs like topiramate. The risk is also higher in people who are 65 or older and in people who are having surgery, an exam or test with contrast, or other procedures. If lactic acidosis happens, it can lead to other health problems and can be deadly. Kidney tests may be done while taking this drug. • Do not take this drug if you have a very bad infection, low oxygen, or a lot of fluid loss (dehydration). • Call your doctor right away if you have signs of too much lactic acid in the blood (lactic acidosis) like confusion; fast breathing; fast or slow heartbeat; a heartbeat that does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; feeling very tired or weak; very bad dizziness; feeling cold; or muscle pain or cramps. • It is used to lower blood sugar in patients with high blood sugar (diabetes). • It is used in certain people to lower the risk of death and having to go to the...

Boxed Warning Lactic acidosis Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Metformin-associated lactic acidosis was characterized by elevated blood lactate levels (>5 mmol/L), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ratio; and metformin plasma levels generally >5 mcg/mL. Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors such as topiramate), age ≥65 years, having a radiological study with contrast, surgery and other procedures, hypoxic states (eg, acute congestive heart failure), excessive alcohol intake, and hepatic impairment. Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided in the full prescribing information. If metformin-associated lactic acidosis is suspected, immediately discontinue and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended. Pharmacology Mechanism of Action See individual agents. Use: Labeled Indications Diabetes mellitus, type 2: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 ...