Megaloblastic anemia is a disorder of impaired DNA synthesis (with normal RNA synthesis) that manifests with the presence of megaloblasts in the bone marrow resulting in ineffective and abnormal erythropoiesis and macrocytes / macroovalocytes in the peripheral blood

That is why this anemia is also called megaloblastic anemia. Causes of this type of anemia include: Too little folic acid in your diet Hemolytic anemia Long-term alcoholism Use of certain medicines (such as phenytoin [Dilantin], methotrexate, sulfasalazine, triamterene, pyrimethamine, trimethoprim-sulfamethoxazole, and barbiturates)

Vitamin B 12 deficiency is a common cause of megaloblastic anemia, various neuropsychiatric symptoms, and other clinical manifestations. Screening average-risk adults for vitamin B 12.

Megaloblastic anemia is a type of macrocytic anemia, which is characterized by defective DNA synthesis and presence of distinct megaloblasts in the bone marrow. This anemia is caused due to the deficiency of Vitamin B12 and/or Folic acid. Less commonly, also due to acquired abnormalities of their metabolism.

The cause is usually a deficiency of either cobalamin (vitamin B 12) or folate, but megaloblastic anemia may occur because of genetic or acquired abnormalities that affect the metabolism of these vitamins or because of defects in DNA synthesis not related to cobalamin or folate . Cobalamin and folate absorption and metabolism are described next.

Megaloblastic anemia is a type of vitamin deficiency anemia that happens when you don’t get enough vitamin B12 and/or vitamin B9 (folate). Healthcare providers treat megaloblastic anemia with vitamin B12 and B9 supplements. Symptoms and Causes Diagnosis and Tests Management and Treatment Prevention Outlook / Prognosis Living With Overview

megaloblastic anemia noun : an anemia (as pernicious anemia) characterized by the presence of megaloblasts in the circulating blood Dictionary Entries Near megaloblastic anemia megaloblast megaloblastic anemia megalocephaly See More Nearby Entries Cite this Entry Style “Megaloblastic anemia.”